位于神奈川县的界星堂综合医院，是日本屈指可数的大医院，某天却突然被戴着鬼面具的武装集团“百鬼夜行”占据，院内上百名医生和职员沦为人质，隶属搜查一课重案组的刑警武藏三郎被卷入其中。武藏因一年前的事件暂时停职，现在与妻子和独生女分居，而作为心脏外科医生任职于该院的妻子竟然也在人质之列！目的不明的武装集团、100多个人质、受困的家人… 分秒不得松懈的大医院挟持事件一触即发！
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